DNA Tumor Viruses and Src Family Tyrosine Kinases, an Intimate Relationship
نویسندگان
چکیده
منابع مشابه
DNA tumor viruses and Src family tyrosine kinases, an intimate relationship.
the Src family of tyrosine kinases are membrane-associReplication of viruses depends on a plethora of ated and act as transducers of signals emanating from highly specific interactions with the host cell resulting plasma membrane receptors, like, e.g., the PDGF recepin the subversion of multiple cellular signal transductor (Kypta et al., 1990) or the B and T cell receptors tion pathways. Cell c...
متن کاملReelin Activates Src Family Tyrosine Kinases in Neurons
BACKGROUND Reelin is a large signaling molecule that regulates the positioning of neurons in the mammalian brain. Transmission of the Reelin signal to migrating embryonic neurons requires binding to the very-low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor-2 (apoER2). This induces tyrosine phosphorylation of the adaptor protein Disabled-1 (Dab1), which interacts with a...
متن کاملRegulation of Btk by Src family tyrosine kinases.
Loss of function of Bruton's tyrosine kinase (Btk) results in X-linked immunodeficiencies characterized by a broad spectrum of signaling defects, including those dependent on Src family kinase-linked cell surface receptors. A gain-of-function mutant, Btk*, induces the growth of fibroblasts in soft agar and relieves the interleukin-5 dependence of a pre-B-cell line. To genetically define Btk sig...
متن کاملDiverse Requirements for Src-Family Tyrosine Kinases Distinguish Chlamydial Species
UNLABELLED Chlamydiae are well known for their species specificity and tissue tropism, and yet the individual species and strains show remarkable genomic synteny and share an intracellular developmental cycle unique in the microbial world. Only a relatively few chlamydial genes have been linked to specific disease or tissue tropism. Here we show that chlamydial species associated with human inf...
متن کاملTau interacts with src-family non-receptor tyrosine kinases.
Tau and other microtubule-associated proteins promote the assembly and stabilization of neuronal microtubules. While each microtubule-associated protein has distinct properties, their in vivo roles remain largely unknown. Tau is important in neurite outgrowth and axonal development. Recently, we showed that the amino-terminal region of tau, which is not involved in microtubule interactions, is ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Virology
سال: 1997
ISSN: 0042-6822
DOI: 10.1006/viro.1996.8316